Supplementary Material for: The Cerebellar-Cerebral Microstructure Is Disrupted at Multiple Sites in Very Preterm Infants with Cerebellar Haemorrhage
Neubauer V.
Djurdjevic T.
Griesmaier E.
Biermayr M.
Gizewski E.R.
Kiechl-Kohlendorfer U.
10.6084/m9.figshare.5579998.v1
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_The_Cerebellar-Cerebral_Microstructure_Is_Disrupted_at_Multiple_Sites_in_Very_Preterm_Infants_with_Cerebellar_Haemorrhage/5579998
<p><b><i>Background:</i></b> Recent advances in magnetic resonance
imaging (MRI) techniques have prompted reconsideration of the anatomical
correlates of adverse outcomes in preterm infants. The importance of
the contribution made by the cerebellum is now increasingly appreciated.
The effect of cerebellar haemorrhage (CBH) on the microstructure of the
cerebellar-cerebral circuit is largely unexplored. <b><i>Objectives:</i></b>
To investigate the effect of CBH on the microstructure of
cerebellar-cerebral connections in preterm infants aged <32
gestational weeks. <b><i>Methods:</i></b> Infants underwent diffusion
tensor MRI at term-equivalent age. MRI was evaluated for CBH and
additional supratentorial brain injury using a validated scoring system.
Region of interest-based measures of brain microstructure (fractional
anisotropy [FA] and apparent diffusion coefficient) were quantified in 5
vulnerable regions (the centrum semiovale, posterior limb of the
internal capsule, corpus callosum, and superior and middle cerebellar
peduncles). Group differences between infants with CBH and infants
without CBH were assessed. <b><i>Results:</i></b> There were 267 infants
included in the study. Infants with CBH (isolated and combined) had
significantly lower FA values in all regions investigated. Infants with
isolated CBH showed lower FA in the middle and superior cerebellar
peduncles and in the posterior limb of the internal capsule. <b><i>Conclusions:</i></b>
This study provides evidence that CBH causes alterations in localised
and remote WM pathways in the developing brain. The disruption of the
cerebellar-cerebral microstructure at multiple sites adds further
support for the concept of developmental diaschisis, which is propagated
as an explanation for the consequences of early cerebellar injury on
cognitive and affective domains.</p>
2017-11-08 13:53:36
Preterm infants
Brain injury
Cerebellar haemorrhage
MRI
Diffusion-tensor imaging
Fractional anisotropy
Apparent diffusion coefficient
Cerebellar-cerebral microstructure