%0 Journal Article %A Z., O'Brien %A A., Cass %A L., Cole %A S., Finfer %A M., Gallagher %A C., McArthur %A S., McGuiness %A J., Myburgh %A R., Bellomo %A J., Mårtensson %A Group, on behalf of the RENAL Study Investigators and the Australian and New Zealand Intensive Care Clinical Trials %D 2017 %T Supplementary Material for: Higher versus Lower Continuous Renal Replacement Therapy Intensity in Critically ill Patients with Liver Dysfunction %U https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Higher_versus_Lower_Continuous_Renal_Replacement_Therapy_Intensity_in_Critically_ill_Patients_with_Liver_Dysfunction/5620597 %R 10.6084/m9.figshare.5620597.v1 %2 https://karger.figshare.com/ndownloader/files/9787120 %K Continuous renal replacement therapy %K Liver dysfunction %K Acute kidney injury %K Mortality %X

Aims: To study the association between higher versus lower continuous renal replacement therapy (CRRT) intensity and mortality in critically ill patients with combined acute kidney injury and liver dysfunction. Methods: Post-hoc analysis of patients with liver dysfunction (Sequential Organ Failure Assessment liver score ≥2 or diagnosis of liver failure/transplant) included in the Randomized Evaluation of Normal versus Augmented Level renal replacement therapy (RENAL) trial. Results: Of 444 patients, 210 (47.3%) were randomized to higher intensity (effluent flow 40 mL/kg/h) and 234 (52.7%) to lower intensity (effluent flow 25 mL/kg/h) therapy. Overall, 79 and 86% of prescribed effluent flow was delivered in the higher-intensity and lower-intensity groups, respectively (p < 0.001). In total, 113 (54.1%) and 120 (51.3%) patients died in each group. On multivariable Cox regression analysis, we found no independent association between higher CRRT intensity and mortality (HR 0.93, 95% CI 0.70-1.24; p = 0.642). Conclusions: In RENAL patients with liver dysfunction, higher CRRT intensity was not associated with reduced mortality.


%I Karger Publishers