10.6084/m9.figshare.5683765.v1
Chang K.-V.
Chang
K.-V.
Chen J.-D.
Chen
J.-D.
Wu W.-T.
Wu
W.-T.
Huang K.-C.
Huang
K.-C.
Hsu C.-T.
Hsu
C.-T.
Han D.-S.
Han
D.-S.
Supplementary Material for: Association between Loss of Skeletal Muscle Mass and Mortality and Tumor Recurrence in Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Karger Publishers
2017
Cancer
Hepatocellular carcinoma
Muscle mass
Sarcopenia
Survival
2017-12-08 10:32:23
Dataset
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Association_between_Loss_of_Skeletal_Muscle_Mass_and_Mortality_and_Tumor_Recurrence_in_Hepatocellular_Carcinoma_A_Systematic_Review_and_Meta-Analysis/5683765
<p><b><i>Background:</i></b> Hepatocellular carcinoma (HCC) has multiple
prognostic factors, and there is an increase in knowledge about the
body composition and physical status of patients with HCC. The present
meta-analysis aimed to explore whether loss of skeletal muscle mass is
associated with mortality and tumor recurrence in patients with HCC. <b><i>Method:</i></b>
A systematic search was conducted for published literature using
PubMed, Embase, and Scopus. We included cohort or case-control studies
investigating patients with HCC. The primary and secondary outcomes were
the associations of loss of skeletal muscle mass with overall survival
and tumor recurrence, respectively, expressed by a summary hazard ratio
(HR) and 95% confidence interval (CI). <b><i>Result:</i></b> A total of
13 studies comprising 3,111 patients were included. The summary HRs
calculated by either univariate or multivariate analysis both suggested a
significant association between sarcopenia and all-cause mortality
(crude HR = 2.04, 95% CI: 1.74-2.38; adjusted HR = 1.95, 95% CI:
1.60-2.37). Similarly, loss of skeletal muscle mass was associated with
tumor recurrence (crude HR = 1.85, 95% CI: 1.44-2.37; adjusted HR =
1.76, 95% CI: 1.27-2.45). The stratified analysis showed that treatment
types and inclusion of body mass index or body weight in the Cox
regression model did not modify both clinical outcomes. With an increase
in cut-off values of muscle mass on computed tomography images
(especially for male patients), there was an insignificant trend of
stronger associations between loss of skeletal muscle mass and all-cause
mortality. <b><i>Conclusion:</i></b> Loss of skeletal muscle mass is
associated with increased all-cause mortality and tumor recurrence in
patients with HCC. Further prospective studies incorporating
measurements of muscle strength and physical function are warranted to
see whether inclusion of both parameters better predicts the outcome
than use of muscle mass only.</p>