Supplementary Material for: Serum Leptin, Resistin, and Adiponectin Concentrations in Psoriasis: A Meta-Analysis of Observational Studies
Kyriakou A.
Patsatsi A.
Sotiriadis D.
Goulis D.G.
10.6084/m9.figshare.5692945.v1
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Serum_Leptin_Resistin_and_Adiponectin_Concentrations_in_Psoriasis_A_Meta-Analysis_of_Observational_Studies/5692945
<p><b><i>Background:</i></b> Psoriasis is an immune-mediated,
inflammatory disease. Adipokines contribute to the regulation of
immune-mediated processes and inflammation. <b><i>Objective:</i></b> The
aim of our study was to systematically review the literature for
studies that have evaluated the circulating concentrations of adipokines
in patients with psoriasis and controls and to meta-analyze the best
evidence available. <b><i>Methods:</i></b> Eligible were studies that
have assessed leptin, resistin, or adiponectin concentrations in
psoriatic patients and a reference group. The study was conducted in
adherence with the PRISMA standards. <b><i>Results:</i></b> Psoriatic
patients had higher leptin concentrations compared to controls (random
effects model, mean difference, MD = 5.64 ng/mL, 95% CI: 3.00-8.29, <i>p</i> < 0.0001). Heterogeneity among studies was high (<i>I</i><sup>2</sup> = 95.9%). Psoriatic patients had higher resistin concentrations compared to controls (MD = 4.66 ng/mL, 95% CI: 2.62-6.69, <i>p</i> < 0.0001). Heterogeneity was high (<i>I</i><sup>2</sup>
= 99.2%). Finally, psoriatic patients had lower adiponectin
concentrations compared to controls (MD = -1.87 μg/mL, 95% CI: -2.76 to
-0.98, <i>p</i> < 0.0001). Heterogeneity was high (<i>I</i><sup>2</sup> = 95.9%). <b><i>Conclusion:</i></b>
The study supported the hypothesis that leptin and resistin
concentrations are higher and adiponectin concentrations are lower in
patients with psoriasis compared to controls. Hereby, the suggested
pathogenic link between psoriasis and metabolic syndrome/obesity is
reinforced and the role of comorbidities in psoriasis is highlighted.</p>
2017-12-12 13:41:05
Leptin
Resistin
Adiponectin
Psoriasis
Adipokines
Meta-analysis