Supplementary Material for: Liver Stiffness Measured by Two-Dimensional Shear-Wave Elastography: Prognostic Value after Radiofrequency Ablation for Hepatocellular Carcinoma
Lee D.H.
Lee J.M.
Yoon J.-H.
Kim Y.J.
Lee J.-H.
Yu S.J.
Han J.K.
10.6084/m9.figshare.5777841.v1
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Liver_Stiffness_Measured_by_Two-Dimensional_Shear-Wave_Elastography_Prognostic_Value_after_Radiofrequency_Ablation_for_Hepatocellular_Carcinoma/5777841
<p><b><i>Purpose:</i></b> To evaluate the prognostic value of liver
stiffness (LS) measured using two-dimensional (2D) shear-wave
elastography (SWE) in patients with hepatocellular carcinoma (HCC)
treated by radiofrequency ablation (RFA). <b><i>Methods:</i></b> The
Institutional Review Board approved this retrospective study and
informed consent was obtained from all patients. A total of 134 patients
with up to 3 HCCs ≤5 cm who had undergone pre-procedural 2D-SWE prior
to RFA treatment between January 2012 and December 2013 were enrolled.
LS values were measured using real-time 2D-SWE before RFA on the
procedural day. After a mean follow-up of 33.8 ± 9.9 months, we analyzed
the overall survival after RFA using the Kaplan-Meier method and Cox
proportional hazard regression model. The optimal cutoff LS value to
predict overall survival was determined using the minimal <i>p</i> value approach. <b><i>Results:</i></b>
During the follow-up period, 22 patients died, and the estimated 1- and
3-year overall survival rates were 96.4 and 85.8%, respectively. LS
measured by 2D-SWE was found to be a significant predictive factor for
overall survival after RFA of HCCs, as was the presence of extrahepatic
metastases. As for the optimal cutoff LS value for the prediction of
overall survival, it was determined to be 13.3 kPa. In our study, 71
patients had LS values ≥13.3 kPa, and the estimated 3-year overall
survival was 76.8% compared to 96.3% in 63 patients with LS values
<13.3 kPa. This difference was statistically significant (hazard
ratio = 4.30 [1.26-14.7]; <i>p</i> = 0.020). <b><i>Conclusion:</i></b> LS values measured by 2D-SWE was a significant predictive factor for overall survival after RFA for HCC.</p>
2018-01-11 14:56:50
Hepatocellular carcinoma
Radiofrequency ablation
Overall survival
Two-dimensional supersonic shear-wave elastography
Liver stiffness measurement