Supplementary Material for: The Effect of a High-Fat Diet on the Development of Abdominal Aortic Aneurysm in a Vascular Hypoperfusion-Induced Animal Model
Hashimoto K.
Kugo H.
Tanaka H.
Iwamoto K.
Miyamoto C.
Urano T.
Unno N.
Hayamizu K.
Zaima N.
Moriyama T.
10.6084/m9.figshare.5827425.v1
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_The_Effect_of_a_High-Fat_Diet_on_the_Development_of_Abdominal_Aortic_Aneurysm_in_a_Vascular_Hypoperfusion-Induced_Animal_Model/5827425
<p>Abdominal aortic aneurysm (AAA) is a vascular disease characterized
by chronic inflammation in the infrarenal aorta. Most cases of AAA
remain asymptomatic until rupture, and the mortality rate of patients
with AAA rupture is very high. Currently, the relation between dietary
habits and AAA development remains unknown. In this study, we evaluated
the effects of a high-fat diet on the development of AAA in a vascular
hypoperfusion-induced animal model. The risk of AAA rupture and AAA
diameter in the high-fat group significantly increased compared with
those in the control group. The number and size of adipocytes in the
vascular wall in the high-fat group significantly increased as compared
with those in the control group. Additionally, the collagen-positive
sections in the areas with adipocytes significantly decreased as
compared with those without adipocytes. The protein levels of matrix
metalloproteinase (MMP)-2, MMP-9, and MMP-12, and macrophage-positive
areas in the parts with adipocytes also significantly increased as
compared with those without adipocytes. These data suggested that AAA
rupture risk increased through accelerating chronic inflammation due to
the accumulation of adipocytes in the vascular wall in the high-fat
group.</p>
2018-01-26 10:41:13
Abdominal aortic aneurysm
Rupture
Triglyceride
Adipocytes
High-fat diet
Matrix metalloproteinase
Inflammation
Macrophages/monocytes
Vascular biology
Lipid metabolism