%0 Journal Article %A F., Peters %A M., Eveslage %A I., Gallitz %A C., Wempe %A P., Meybohm %A Van Aken H. %A A., Steinbicker %D 2018 %T Supplementary Material for: Post-Operative Iron Carboxymaltose May Have an Effect on Haemoglobin Levels in Cardiothoracic Surgical Patients on the ICU - an Observational Pilot Study about Anaemia Treatment with Intravenous Iron %U https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Post-Operative_Iron_Carboxymaltose_May_Have_an_Effect_on_Haemoglobin_Levels_in_Cardiothoracic_Surgical_Patients_on_the_ICU_-_an_Observational_Pilot_Study_about_Anaemia_Treatment_with_Intravenous_Iron/5835690 %R 10.6084/m9.figshare.5835690.v1 %2 https://karger.figshare.com/ndownloader/files/10331013 %K Intensive care unit %K Anaemia %K Ferric carboxymaltose %K Blood transfusions %X

Background: Post-operative anaemia is associated with increased morbidity and mortality. Positive effects of post-operative intravenous iron (IVI) after elective orthopaedic, abdominal and genitourinary surgery have been reported. The current observational trial investigated the prevalence of post-operative anaemia, the effect of IVI on haemoglobin levels, the use of blood transfusions and diagnoses related to infections. Methods: 1,265 patients on five ICUs of Münster University Hospital were screened for post-operative anaemia. On one ICU, patients were screened for iron deficiency and, if indicated, supplemented with 500 mg of ferric carboxymaltose. Primary outcome measures were haemoglobin levels, C-reactive protein, white blood cell count, transfusion requirements, documented infection and antibiotic treatment. Results: Anaemia was prevalent in 86.2% of patients upon ICU admission. 429 patients were screened for iron deficiency anaemia. 95 patients were eligible, 35 were treated with IVI. An increase of +0.4 g/dl in Hb levels 7 days after IVI compared to -0.1 g/dl in non-treated anaemic patients was observed. The number of RBC transfusions, ICD codes related to infections and infectious parameters were similar between groups. Conclusions: IVI treatment was safe and resulted in higher median Hb levels. Randomized controlled trials are required to support the hypotheses of this study.

%I Karger Publishers