%0 Generic %A D., Saengpanit %A P., Chattranukulchai %A M., Tumkosit %A M., Siribumrungwong %A P., Katavetin %A V., Sitprija %A K., Praditpornsilpa %A S., Eiam-Ong %A P., Susantitaphong %D 2018 %T Supplementary Material for: Effect of Sodium Thiosulfate on Arterial Stiffness in End-Stage Renal Disease Patients Undergoing Chronic Hemodialysis (Sodium Thiosulfate-Hemodialysis Study): A Randomized Controlled Trial %U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Effect_of_Sodium_Thiosulfate_on_Arterial_Stiffness_in_End-Stage_Renal_Disease_Patients_Undergoing_Chronic_Hemodialysis_Sodium_Thiosulfate-Hemodialysis_Study_A_Randomized_Controlled_Trial/6021599 %R 10.6084/m9.figshare.6021599.v1 %2 https://karger.figshare.com/ndownloader/files/10836254 %K Arterial stiffness %K Cardio-ankle vascular index %K Coronary artery calcification %K End-stage renal disease %K Hemodialysis %K Vascular calcification %X Background: Arterial stiffness (AS) and vascular calcification are significantly related to a high cardiovascular mortality risk in hemodialysis (HD) patients. Intravenous sodium thiosulfate (IV STS) can prevent and delay the vascular calcification progression in uremic states; however, the STS effect on AS has not been assessed. This study aimed to evaluate the STS efficacy on vascular calcification and AS in HD patients. Methods: Fifty HD patients with abnormal AS, as measured via the cardio-ankle vascular index (CAVI ≥8), were prospectively randomized to open-label 12.5 g IV STS during the last HD hour twice weekly for 6 months (n = 24) or the usual care (control group; n = 26). Patients and treating physicians were not blinded. The CAVI, coronary artery calcification (CAC) score, hemodynamics, and biochemical parameters were measured at the baseline and at 3 and 6 months. Results: All the baseline parameters were comparable. The IV STS significantly reduced the CAVI when compared to the control group (mean CAVI difference = –0.53; 95% CI –1.00 to –0.06; p = 0.03). A significant CAVI improvement was seen in those patients without diabetes mellitus. The natural logarithm of the CAC volume score was significantly increased in the control group. The high sensitivity C-reactive protein level was slightly lowered in the IV STS group (not significant). Conclusion: The intradialytic STS treatment significantly reduced the AS, as measured by the CAVI, and stabilized the vascular calcification in the HD patients. STS may be a novel therapeutic strategy for delaying and treating the structural and functional vascular wall abnormalities in HD patients. %I Karger Publishers