%0 Generic
%A R., Muniyappa
%A R.A., Noureldin
%A K.Z., Abd-Elmoniem
%A R.H., El Khouli
%A J.R., Matta
%A A., Hamimi
%A S., Ranganath
%A C., Hadigan
%A L.K., Nieman
%A A.M., Gharib
%D 2018
%T Supplementary Material for: Personalized Statin Therapy and Coronary Atherosclerotic Plaque Burden in Asymptomatic Low/Intermediate-Risk Individuals
%U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Personalized_Statin_Therapy_and_Coronary_Atherosclerotic_Plaque_Burden_in_Asymptomatic_Low_Intermediate-Risk_Individuals/6021716
%R 10.6084/m9.figshare.6021716.v1
%2 https://karger.figshare.com/ndownloader/files/10836386
%2 https://karger.figshare.com/ndownloader/files/10836389
%K Atherosclerosis
%K Coronary computed tomography angiography
%K Personalized therapy
%K Statin therapy
%X Background: Current guidelines for the primary prevention of atherosclerotic cardiovascular disease are based on the estimation of a predicted 10-year cardiovascular disease risk and the average relative risk reduction estimates from statin trials. In the clinical setting, however, decision-making is better informed by the expected benefit for the individual patient, which is typically lacking. Consequently, a personalized statin benefit approach based on absolute risk reduction over 10 years (ARR10 benefit threshold ≥2.3%) has been proposed as a novel approach. However, how this benefit threshold relates with coronary plaque burden in asymptomatic individuals with low/intermediate cardiovascular disease risk is unknown. Aims: In this study, we compared the predicted ARR10 obtained in each individual with plaque burden detected by coronary computed tomography angiography. Methods and Results: Plaque burden (segment volume score, segment stenosis score, and segment involvement score) was assessed in prospectively recruited asymptomatic subjects (n = 70; 52% male; median age 56 years [interquartile range 51–64 years]) with low/intermediate Framingham risk score (< 20%). The expected ARR10 with statin in the entire cohort was 2.7% (1.5–4.6%) with a corresponding number needed to treat over 10 years of 36 (22–63). In subjects with an ARR10 benefit threshold ≥2.3% (vs. < 2.3%), plaque burden was significantly higher (p = 0.02). Conclusion: These findings suggest that individuals with higher coronary plaque burden are more likely to get greater benefit from statin therapy even among asymptomatic individuals with low cardiovascular risk.
%I Karger Publishers