%0 Generic %A C., Lee %A Y.A., Eom %A H., Yang %A M., Jang %A S.U., Jung %A Y.O., Park %A S.E., Lee %A H., Jung %D 2018 %T Supplementary Material for: Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches %U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Skin_Barrier_Restoration_and_Moisturization_Using_Horse_Oil-Loaded_Dissolving_Microneedle_Patches/6097616 %R 10.6084/m9.figshare.6097616.v1 %2 https://karger.figshare.com/ndownloader/files/10986623 %2 https://karger.figshare.com/ndownloader/files/10986626 %2 https://karger.figshare.com/ndownloader/files/10986629 %2 https://karger.figshare.com/ndownloader/files/10986632 %2 https://karger.figshare.com/ndownloader/files/10986635 %2 https://karger.figshare.com/ndownloader/files/10986638 %2 https://karger.figshare.com/ndownloader/files/10986644 %2 https://karger.figshare.com/ndownloader/files/10986647 %2 https://karger.figshare.com/ndownloader/files/10986656 %K Skin barrier restoration %K Skin barrier function %K Moisturization %K Horse oil %K Microneedle %K Dermal therapy %K Clinical practice %X Background: Horse oil (HO) has skin barrier restoration and skin-moisturizing effects. Although cream formulations have been used widely and safely, their limited penetration through the stratum corneum is a major obstacle to maximizing the cosmetic efficacy of HO. Therefore, we aimed to encapsulate HO in a cosmetic dissolving microneedle (DMN) for efficient transdermal delivery. Methods: To overcome these limitations of skin permeation, HO-loaded DMN (HO-DMN) patches were developed and evaluated for their efficacy and safety using in vitro and clinical studies. Results: Despite the lipophilic nature of HO, the HO-DMN patches had a sharp shape and uniform array, with an average length and tip diameter of 388.36 ± 16.73 and 38.54 ± 5.29 µm, respectively. The mechanical strength of the HO-DMN patches was sufficient (fracture force of 0.29 ± 0.01 N), and they could successfully penetrate pig skin. During the 4-week clinical evaluation, HO-DMN patches caused significant improvements in skin and dermal density, skin elasticity, and moisturization. Additionally, a brief safety assessment showed that the HO-DMN patches induced negligible adverse events. Conclusion: The HO-DMNs are efficient, safe, and convenient for wide use in cosmetic applications for skin barrier restoration and moisturization. %I Karger Publishers