Supplementary Material for: Extracorporeal Photopheresis: An Efficacious and Well-Tolerated Treatment for Cutaneous and Oral Mucosal Chronic Graft-versus-Host Disease Richet C. Huynh A. Dimeglio C. Borel C. Lepage B. Boulinguez S. Marguery M.C. Paul C. Bulai Livideanu C. 10.6084/m9.figshare.6303926.v1 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Extracorporeal_Photopheresis_An_Efficacious_and_Well-Tolerated_Treatment_for_Cutaneous_and_Oral_Mucosal_Chronic_Graft-versus-Host_Disease/6303926 <b><i>Background:</i></b> Extracorporeal photopheresis (ECP) is a second-line therapy for steroid-refractory chronic graft-versus-host disease (cGVHD). <b><i>Objective:</i></b> We describe the long-term efficacy and tolerability of ECP according to the cutaneous phenotype of cGVHD and report on the reduced need for immunosuppressant drugs in this setting. <b><i>Patients and Methods:</i></b> Fourteen patients (8 females) with cutaneous and/or mucosal cGVHD, treated with ECP between October 2010 and May 2016 within a single center, were included. Final analyses included patients who had received ECP for at least 12 months. We prospectively evaluated the efficacy of ECP using lesion-specific clinical scores and by recording changed doses of systemic immunosuppressants. <b><i>Results:</i></b> Of the 14 patients, sclerotic skin lesions were present in 10 (71%). The mRODNAN score decreased in all patients from month 9 onwards, with 40 and 77% reductions at 12 and 36 months, respectively. Six patients (43%) presented with cutaneous lichenoid lesions: this score was reduced in all patients by month 3, reaching a 93% reduction by month 12. Five patients (36%) experienced oral mucosal lichenoid lesions: these scores were decreased by 55% at month 12 and by 100% by month 33. The use of systemic immunosuppressants was reduced in all patients; 4 patients could stop all immunosuppressant drugs after 2 years. ECP was stopped in 3 patients after a complete response. No major ECP-associated adverse effects were observed. <b><i>Discussion and Conclusion:</i></b> ECP was an effective long-term therapy for oral and cutaneous cGVHD: consequently, dose levels of therapeutic immunosuppression could be reduced. 2018-05-22 14:09:13 Chronic graft-versus-host disease Extracorporeal photopheresis Sclerotic graft-versus-host disease Lichenoid graft-versus-host disease