10.6084/m9.figshare.6729347.v1
Genis-Mendoza A.D.
Genis-Mendoza
A.D.
López-Narvaez M.L.
López-Narvaez
M.L.
Tovilla-Zárate C.A.
Tovilla-Zárate
C.A.
Sarmiento E.
Sarmiento
E.
Chavez A.
Chavez
A.
Martinez-Magaña J.J.
Martinez-Magaña
J.J.
González-Castro T.B.
González-Castro
T.B.
Hernández-Díaz Y.
Hernández-Díaz
Y.
Juárez-Rojop I.E.
Juárez-Rojop
I.E.
Ávila-Fernández Á.
Ávila-Fernández
Á.
Nicolini H.
Nicolini
H.
Supplementary Material for: Association between Polymorphisms of the DRD2 and ANKK1 Genes and Suicide Attempt: A Preliminary Case-Control Study in a Mexican Population
Karger Publishers
2018
Dopamine
Gene
DRD2 gene
ANKK1 gene
Suicide
2018-07-02 11:49:32
Dataset
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Association_between_Polymorphisms_of_the_DRD2_and_ANKK1_Genes_and_Suicide_Attempt_A_Preliminary_Case-Control_Study_in_a_Mexican_Population/6729347
<b><i>Background:</i></b> The aim of this study was to analyze the possible association of polymorphic variants of the <i>DRD2</i> and <i>ANKK1</i> genes with suicide attempt in a Mexican population. <b><i>Methods:</i></b> We conducted a case-control study in 289 subjects (166 suicide attempters and 123 healthy controls). We genotyped 2 polymorphisms of <i>DRD2</i> (rs6275 and rs1799978) and 1 polymorphism of <i>ANKK1</i> (rs1800497); then we analyzed the association between suicide attempt and these polymorphisms through genotypes, alleles, and inheritance models. <b><i>Results:</i></b> Individuals who carried the TT genotype of the rs1800497 showed a 3-fold risk of attempting suicide (OR = 3.01; 95% CI 1.56–5.81, <i>p</i> = 0.001) when evaluated through the recessive model. In an analysis stratified by gender, this risk factor remained present among females (OR = 2.81; 95% CI 1.37–5.75) as well as males (OR = 3.3; 95% CI 1.01–10.77). <b><i>Conclusion:</i></b> Our results suggest that the rs1800497 variant of the <i>ANKK1</i> gene could increase the risk of suicide attempt in a Mexican population. However, further studies using larger samples are necessary to obtain more conclusive results.