10.6084/m9.figshare.6796838.v4
Gassner C.
Gassner
C.
Degenhardt F.
Degenhardt
F.
Meyer S.
Meyer
S.
Vollmert C.
Vollmert
C.
Trost N.
Trost
N.
Neuenschwander K.
Neuenschwander
K.
Merki Y.
Merki
Y.
Portmann C.
Portmann
C.
Sigurdardottir S.
Sigurdardottir
S.
Zorbas A.
Zorbas
A.
Engström C.
Engström
C.
Gottschalk J.
Gottschalk
J.
Amar el Dusouqui S.
Amar el Dusouqui
S.
Waldvogel-Abramovski S.
Waldvogel-Abramovski
S.
Rigal E.
Rigal
E.
Tissot J.-D.
Tissot
J.-D.
Tinguely C.
Tinguely
C.
Mauvais S.M.
Mauvais
S.M.
Sarraj A.
Sarraj
A.
Bessero D.
Bessero
D.
Stalder M.
Stalder
M.
Infanti L.
Infanti
L.
Buser A.
Buser
A.
Sigle J.
Sigle
J.
Weingand T.
Weingand
T.
Castelli D.
Castelli
D.
Braisch M.C.
Braisch
M.C.
Thierbach J.
Thierbach
J.
Heer S.
Heer
S.
Schulzki T.
Schulzki
T.
Krawczak M.
Krawczak
M.
Franke A.
Franke
A.
Frey B.M.
Frey
B.M.
Supplementary Material for: Low-Frequency Blood Group Antigens in Switzerland
Karger Publishers
2018
Blood groups
Low-frequency antigen
High-frequency antigen
Rare donor panel/program
Rare/molecular blood group
Blood group allele
Population genetics
Switzerland
2018-07-12 10:54:27
Dataset
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Low-Frequency_Blood_Group_Antigens_in_Switzerland/6796838
Background: High-frequency blood group antigens (HFA) are present in >90% of the human population, according to some reports even in >99% of individuals. Therefore, patients lacking HFA may become challenging for transfusion support because compatible blood is hardly found, and if the patient carries alloantibodies, the crossmatch will be positive with virtual every red cell unit tested. Methods: In this study, we applied high-throughput blood group SNP genotyping on >37,000 Swiss blood donors, intending to identify homozygous carriers of low-frequency blood group antigens (LFA). Results: 326 such individuals were identified and made available to transfusion specialists for future support of patients in need of rare blood products. Conclusion: Thorough comparison of minor allele frequencies using population genetics revealed heterogeneity of allele distributions among Swiss blood donors which may be explained by the topographical and cultural peculiarities of Switzerland. Moreover, geographically localized donor subpopulations are described which contain above-average numbers of individuals carrying rare blood group genotypes.