Supplementary Material for: Increasing the Sensitivity of Functional Status Assessment in the Preclinical Range (Normal to Mild Cognitive Impairment): Exploring the IADL-Extended Approach Fieo R. Stern Y. 10.6084/m9.figshare.6803417.v1 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Increasing_the_Sensitivity_of_Functional_Status_Assessment_in_the_Preclinical_Range_Normal_to_Mild_Cognitive_Impairment_Exploring_the_IADL-Extended_Approach/6803417 <b><i>Background/Aims:</i></b> Dementia exhibits an insidious onset consisting of cognitive, behavioral, and functional impairment. We explored a functional continuum that extends assessment beyond the clinical instrumental activities of daily living (IADL) range and into advanced activities of daily living. <b><i>Methods:</i></b> We examined the predictive power (Cox regression; <i>n</i> = 2,471) of a unidimensional IADL-extended (IADL-x) scale for incident mild cognitive impairment (MCI). We also examined “time to MCI” as an outcome measure. <b><i>Results:</i></b> Each additional task endorsed on the IADL-x hierarchy (e.g., endorsing participation in 6 vs. 5 activities) resulted in a 10% reduction in MCI risk (HR 0.90, 95% CI 0.85–0.94, <i>p</i> < 0.001). For the fully adjusted model the risk reduction dropped to 6%. The odds of incident MCI within 2 years (for those below the median IADL-x total score) was 2.5 times higher (OR 2.60, 95% CI 1.52–4.4, <i>p</i> < 0.001) and 2 times higher for incident MCI within the next 5 years (OR 1.93, 95% CI 1.76–3.2, <i>p</i> < 0.01). <b><i>Conclusion:</i></b> The IADL-x metric appears to be a valid approach for determining the risk of MCI based on one’s position along a formal hierarchy of function. 2018-07-11 08:17:14 Mild cognitive impairment Functional status Preclinical dementia Cognition