P., Lucas S., Boulinguez V., Sibaud L., Mourey L., Lamant C., Paul N., Meyer Supplementary Material for: Characterization and Outcomes of Disease Progression in 52 Patients Treated with <b><i>BRAF</i></b>-V600 + MEK Inhibitors for Advanced Melanoma <b><i>Background:</i></b> Combined treatment with <i>BRAF</i>-V600 and MEK inhibitors has significantly improved progression-free and overall survival of patients with <i>BRAF</i>-mutated melanoma. Pattern of disease progression and outcomes in patients have not been fully characterized. <b><i>Methods:</i></b> We conducted a single-center, retrospective, descriptive analysis of a cohort of 52 patients treated with <i>BRAF</i>-V600 + MEK inhibitors for advanced melanoma over a 12-month period. The aim of this study was to characterize disease progression, defined as metastatic pattern, disease kinetics, and response to subsequent therapies, in melanoma patients treated with <i>BRAF</i>-V600 + MEK inhibitors. <b><i>Results:</i></b> Disease progression was observed in 31/52 (59.6%) patients treated with <i>BRAF</i>-V600 + MEK inhibitors. Relapse of melanoma involved the CNS for 22/31 (70.9%) patients with disease progression, including 18/31 (58%) patients who had exclusive intracranial metastases. Sixteen patients died from disease progression. Among the 31 patients who had disease progression, the median time until a relapse was 8 months, and the median survival time after disease progression was 2 months. <b><i>Conclusion:</i></b> Our study shows that, for patients treated with <i>BRAF</i>-V600 + MEK inhibitors who lose response, disease progression was aggressive and had poor outcomes. Most patients had CNS metastases and low rates of therapeutic response to any subsequent therapy. Melanoma;BRAF inhibitor;MEK inhibitor;Dabrafenib;Vemurafenib 2018-08-15
    https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Characterization_and_Outcomes_of_Disease_Progression_in_52_Patients_Treated_with_b_i_BRAF_i_b_-V600_MEK_Inhibitors_for_Advanced_Melanoma/6970040
10.6084/m9.figshare.6970040.v1