10.6084/m9.figshare.7257302.v1 Tollár J. Tollár J. Nagy F. Nagy F. Hortobágyi T. Hortobágyi T. Supplementary Material for: Vastly Different Exercise Programs Similarly Improve Parkinsonian Symptoms: A Randomized Clinical Trial Karger Publishers 2018 Exercise specificity Balance training Posture Quality of life 2018-10-26 09:33:11 Dataset https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Vastly_Different_Exercise_Programs_Similarly_Improve_Parkinsonian_Symptoms_A_Randomized_Clinical_Trial/7257302 <b><i>Objectives:</i></b> To directly compare the effects of agility exergaming (EXE) and stationary cycling (CYC) exercise training on Parkinson’s disease (PD) patients’ mobility and clinical symptoms. <b><i>Design:</i></b> Randomized clinical trial. <b><i>Setting:</i></b> Outpatient physiotherapy clinic in a hospital. <b><i>Participants:</i></b> Seventy-four stage 2–3, nondemented PD patients were included in this study. <b><i>Intervention:</i></b> The groups were as follows: EXE (<i>n</i> = 25), CYC (<i>n</i> = 25), and a wait-listed control group (CON; <i>n</i> = 24). The EXE and CYC groups exercised 5×/week for 5 weeks, matched at 80% of the age-predicted maximal heart rate. <b><i>Main Outcomes:</i></b> The primary outcome was the Movement Disorders Society Unified Parkinson’s Disease Rating Scale (UPDRS-II) score. Secondary outcomes were Parkinson’s Disease Quastionnaire-39 (PDQ-39), the Beck Depression Inventory (BDI), the Schwab and England Activities of Daily Living (SE-ADL) scale, Euro-Quality of Life-5 Dimensions (EQ-5D) questionnaire, the Berg Balance Scale (BBS), the Balance Evaluation Systems Test (BESTest), the Tinetti Assessment Tool (TAT), the Dynamic Gait Index, the 6-min walk test (6MWT), and standing posturography. <b><i>Results:</i></b> After treatment, UPDRS-II scores improved (mean change: EXE, –4.5 points; CYC, –3.2 points). The results for the other outcomes (EXE and CYC, respectively) were: PDQ, 13 and 17%; BDI, –2.5 and –2.1 points; 6MWT, 129.6 and 141.6 m; and EQ-5D, 12 and 9% (all <i>p</i> < 0.05, but there was no difference between groups). EXE vs. CYC resulted in improved SE-ADL (8.4 and 4.0 points, effect size [ES]: 0.12), BBS (8.8 and 4.2 points, ES: 0.44), and 2 measures of posturography (ES: 0.11 and 0.21) (<i>p</i> < 0.05). BESTtest, TAT, the Dynamic Gait Index, and 4 out of 6 posturography measures did not change (<i>p</i> > 0.05). <b><i>Conclusion:</i></b> Two highly different exercise programs resulted in similar improvement of most motor and clinical symptoms in PD patients.