Supplementary Material for: Can Early Introduction of Palliative Care Limit Intensive Care, Emergency and Hospital Admissions in Patients with Severe Chronic Obstructive Pulmonary Disease? A Pilot Randomized Study Janssens J.-P. Weber C. Herrmann F.R. Cantero C. Pessina A. Matis C. MerletViollet R. Boiche-Brouillard L. Stirnemann J. Pautex S. 10.6084/m9.figshare.7593992.v1 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Can_Early_Introduction_of_Palliative_Care_Limit_Intensive_Care_Emergency_and_Hospital_Admissions_in_Patients_with_Severe_Chronic_Obstructive_Pulmonary_Disease_A_Pilot_Randomized_Study/7593992 <b><i>Background:</i></b> Despite their poor prognosis, patients with severe chronic obstructive pulmonary disease (COPD) have little access to palliative care and tend to have a high rate of hospital and intensive care unit (ICU) admissions during their last year of life. <b><i>Objectives:</i></b> To determine the feasibility of a home palliative care intervention during 1 year versus usual care, and the possible impact of this intervention on emergency, hospital and ICU admissions, survival, mood, and health-related quality of life (HRQL). <b><i>Methods:</i></b> Prospective controlled study of patients with severe COPD (GOLD stage III or IV) and long-term oxygen therapy and/or home noninvasive ventilation and/or one or more hospital admissions in the previous year for acute exacerbation, randomized to usual care versus usual care with add-on monthly intervention by palliative care specialists at home for 12 months. <b><i>Results:</i></b> Of 315 patients screened, 49 (15.5%) were randomized (26 to early palliative care; 23 to the control group); aged (mean ± SD) 71 ± 8 years; FEV<sub>1</sub> was 37 ± 14% predicted; 88% with a COPD assessment test score > 10; 69% on long-term oxygen therapy or home noninvasive ventilation. The patients accepted the intervention and completed the assessment scales. After 1 year, there was no difference between groups in symptoms, HRQL and mood, and there was a nonsignificant trend for higher admission rates to hospital and emergency wards in the intervention group. <b><i>Conclusion:</i></b> Although this pilot study was underpowered to formally exclude a benefit from palliative care in severe COPD, it raises several questions as to patient selection, reluctance to palliative care in this group, and modalities of future trials. 2019-01-16 12:52:51 Chronic obstructive pulmonary disease Palliative care Long-term oxygen therapy Home noninvasive ventilation Symptom control