X., Li J., Chen D., Cheng W., Wang K., Xie M., Zhang F., Xu J., Wen Z., Tang Supplementary Material for: Histopathologic Features that Predict Transplant Glomerulopathy Progression in a Chinese Cohort <b><i>Background:</i></b> Transplant glomerulopathy (TG) represents a major cause of long-term allograft failure and is the leading cause of overall post-transplant proteinuria. The extent to which histopathologic features predicts prognostication is uncertain. <b><i>Methods:</i></b> A single-center retrospective cohort with biopsy-proven TG was investigated. Renal biopsies were scored according to Banff 2017. The primary outcome was death-censored graft failure defined as return to dialysis or estimated glomerular filtration rate (eGFR) decreased to <15 mL/min/1.73 m<sup>2</sup>. The prognostic significance of clinical and histopathologic parameters was determined using Cox proportional hazards models. <b><i>Results:</i></b> Data from 180 cases were available for analysis with a median follow-up of 5.0 (2.6–8.2) years. In multivariable models, ci + ct score (HR 3.1; 95% CI 2.0–4.9), cg score (HR 1.7; 95% CI 1.1–2.8), eGFR (HR 2.1; 95% CI 1.4–3.2) and proteinuria (HR 2.4; 95% CI 1.6–3.7) were independent predictors of the primary outcome. Mesangial Immunoglobulin A deposition did not significantly affect allograft survival. The only significant pathologic factors for the severity of proteinuria were cg and g + ptc (adjusted <i>R</i><sup>2</sup> = 0.46) as determined by multivariable stepwise linear regression analysis. <b><i>Conclusions:</i></b> Severe ci + ct and cg at biopsy were predictors of unfavorable allograft prognosis in TG patients even after taking into consideration clinical characteristics. Histologic severity of cg and g + ptc was significantly associated with clinical proteinuria. Transplant glomerulopathy;Renal survival;Risk factors;Histopathology 2019-04-16
    https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Histopathologic_Features_that_Predict_Transplant_Glomerulopathy_Progression_in_a_Chinese_Cohort/7998296
10.6084/m9.figshare.7998296.v1