Supplementary Material for: Distribution and Determinants of <b><i>Dermatophagoides</i></b> Mites Sensitization ofAllergic Rhinitis and Allergic Asthma in China Chen Z.-G. Li Y.-T. Wang W.-H. Tan K.-S. Zheng R. Yang L.-F. Guan W.-J. Hong H.-Y. Yang Q.-T. 10.6084/m9.figshare.8143172.v1 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Distribution_and_Determinants_of_b_i_Dermatophagoides_i_b_Mites_Sensitization_ofAllergic_Rhinitis_and_Allergic_Asthma_in_China/8143172 <b><i>Background:</i></b> The implementation of allergen immunotherapy (AIT) requires extensive knowledge of allergen distribution in the region to identify high-risk regions for AIT utilization. However, the geographical distribution patterns of the major <i>Dermatophagoides</i> allergens in China remain unclear despite the increasing prevalence of these allergens. <b><i>Methods:</i></b> We performed comprehensive database searches of articles demonstrating the distribution patterns of <i>Dermatophagoides</i>-sensitized allergic rhinitis (AR) and allergic asthma (AA) in China, published between 1990 and 2017. <b><i>Results:</i></b> We retrieved 163 articles encompassing 114,302 allergen-positive cases to generate the distribution maps. The rate of sensitization to <i>Dermatophagoides</i> <i>pteronyssinus</i>(<i>D. pteronyssinus</i>)<i></i>and <i>Dermatophagoides</i> <i>farinae</i> (<i>D. farinae</i>) was similar in patients with AR (75.1 vs. 75.2%, <i>p</i> > 0.05) but not in those with AA (78.5 vs. 77.7%, <i>p</i> = 0.041). Patients with AR and AA shared similar regional distribution patterns of both <i>D. pteronyssinus</i> and <i>D. farinae</i> sensitization, which were highest in the southern and central parts of China and lowest in the northern regions, especially in the Northwest. The overall rate of sensitization to <i>D. pteronyssinus</i> and <i>D. farinae</i> was significantly higher in patients with AA (<i>p</i> < 0.001). Additionally, the annual mean temperature and humidity were the 2 major determinants of <i>D. pteronyssinus</i> and <i>D. farinae</i> sensitization in AR and of <i>D. pteronyssinus</i> sensitization in AA, whereas the annual mean temperature was the sole determinant for <i>D. farinae</i> sensitization in AA. <b><i>Conclusion:</i></b> These findings may inform clinicians of the strategies for the prevention of <i>Dermatophagoides</i> sensitization and may be of benefit to the future clinical management of allergic diseases<i></i>associated with sensitization to <i>Dermatophagoides</i> mites. 2019-05-17 08:44:07 Allergic rhinitis Allergic asthma Dermatophagoides mite Sensitization