S., Onoe A., Maeda Y., Takayama Y., Fukami T., Takahashi M., Uji Y., Kaneoka Supplementary Material for: The Prognostic Impact of the Lymphocyte-to-Monocyte Ratio in Resected Pancreatic Head Adenocarcinoma <b><i>Objective:</i></b> Although the prognostic significance of systematic inflammation-based scores, such as the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the prognostic nutritional index (PNI), has been explored in pancreatic cancers, few reports have investigated the lymphocyte-to-monocyte ratio (LMR). We aimed to retrospectively investigate the prognostic value of the preoperative LMR in patients with resectable pancreatic head cancer (PHC). <b><i>Methods:</i></b> From 2005 to 2016, 165 patients underwent pancreatoduodenectomy for PHC. All samples of peripheral blood were collected within 2 weeks prior to surgery. The best cutoff values of the LMR for predicting survival were determined by using a minimum <i>p</i> value approach (cut-off value: 2.8). The clinicopathological features of LMR <2.8 (<i>n</i> = 25) and ≥2.8 (<i>n</i> = 140) were compared. <b><i>Results:</i></b> Patients with LMR ≥2.8 showed significantly lower NLR and PLR, and significantly higher PNI. Levels of CEA and CA19-9 were similar, and the pathological findings were comparable between the groups. The overall survival of patients with LMR ≥2.8 (66.2% at 1 year) was superior to that of patients with LMR <2.8 (36.1% at 1 year, <i>p</i> = 0.015). Multivariate analysis identified LMR <2.8 (hazard ratio 1.72, 95% CI 1.02–2.89, <i>p</i> = 0.042), lymphatic and venous invasion and positive surgical margin as independent prognostic factors. <b><i>Conclusions:</i></b> LMR may carry important prognostic information for patients with resectable PHC. Preoperative LMR may be considered for use in risk stratification for individual patients with PHC. Lymphocyte-to-monocyte ratio;Pancreatic head adenocarcinoma;Systematic inflammation-based scores 2019-08-06
    https://karger.figshare.com/articles/dataset/Supplementary_Material_for_The_Prognostic_Impact_of_the_Lymphocyte-to-Monocyte_Ratio_in_Resected_Pancreatic_Head_Adenocarcinoma/9255671
10.6084/m9.figshare.9255671.v1