Supplementary Material for: Multimodal Clinical Imaging Assessment of the Outcome in Mild-to-Moderate Acne: A Prospective Study Kyrgidis A. Becker M. Zampeli V. Fauger A. Sayag M. Zouboulis C.C. 10.6084/m9.figshare.9300983.v1 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Multimodal_Clinical_Imaging_Assessment_of_the_Outcome_in_Mild-to-Moderate_Acne_A_Prospective_Study/9300983 <b><i>Background:</i></b> The quality of outcome assessment in acne studies has been either subjective/insufficient or time consuming through the ordinary lesion counting. <b><i>Objective:</i></b> To evaluate the application of multimodal clinical imaging (MCI), a combination of imaging technology and computation, in the assessment of acne lesions in a clinical study setting. <b><i>Methods:</i></b> A prospective, monocentric, single-group open study designed to evaluate the efficacy and tolerance of a cosmetic product (IP/SG) in subjects with mild-to-moderate facial acne by classical clinical counting (CCC) – change in the total/inflammatory/noninflammatory acne lesion number compared with baseline (D0) – Investigator Global Assessment (IGA) and self-reported outcomes. Concomitantly, MCI was administered. The study was performed for 12 weeks (D84) with a 4-week follow-up (D112). <b><i>Results:</i></b> Mean age of patients (<i>n</i> = 49) was 18.2 ± 3.7 years (range 13–25). The mean acne duration was 3.8 ± 2.8 years. The total number of lesions did not differ significantly between D0/D84 by both CCC and MCI. However, the Cardiff Acne Disability Index (CADI) and uncomfortable feeling improved at D28/D0, the perception of oily skin improved at D14/D0, and the perception of sticky skin improved from D28/D0 to D56/D0. Deterioration was detected between D84/D0 and D112/D0, namely after product discontinuation. Interestingly, a change in trend was recorded for acne lesions at D14/D0 by MCI but not by CCC. <b><i>Conclusion:</i></b> MCI, applied for the first time in a small clinical study setting, is at least as reliable as CCC and may allow for a sensitive longitudinal evaluation of single acne lesions and their response to products, especially in conditions where clinical evaluation reaches its limits. 2019-08-07 09:30:15 Acne Clinical trial Cosmetics Dermatology life quality index Digital imaging Outcome Quality of life Skin inflammation