%0 Generic %A M.C., Herwig-Carl %A K.U., Loeffler %D 2019 %T Supplementary Material for: Regression of Periocular Basal Cell Carcinoma: A Report of Four Cases with Clinicopathologic Correlation %U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Regression_of_Periocular_Basal_Cell_Carcinoma_A_Report_of_Four_Cases_with_Clinicopathologic_Correlation/9742184 %R 10.6084/m9.figshare.9742184.v1 %2 https://karger.figshare.com/ndownloader/files/17448746 %2 https://karger.figshare.com/ndownloader/files/17448749 %2 https://karger.figshare.com/ndownloader/files/17448752 %2 https://karger.figshare.com/ndownloader/files/17448755 %K Basal cell carcinoma %K Tumor regression %K Histology %K T lymphocytes %X Objectives: To describe the spectrum of clinical and histopathological features of a case series of basal cell carcinoma (BCC) with spontaneous regression and to discuss this phenomenon. Method: Four cases of BCC with complete/substantial regression were retrospectively identified. Patients’ records were analyzed for demographic data, clinical appearance, and the postoperative course. Formalin-fixed, paraffin-embedded specimens were routinely processed and stained with hematoxylin and eosin and periodic acid Schiff. Results: Complete (n = 1) or partial (n = 3) regression of BCC was observed in 4 patients. Two lesions at the medial canthus were histologically diagnosed as nodular BCC with significant regression. One lesion at the lower eyelid exhibited a complete regression which did not require surgical intervention. The other lesion at the lower eyelid presenting with ulceration and madarosis was excised. Scar tissue without evidence for a neoplasm was present histologically. Subsequently, the patient developed a recurrence with a histologically proven micronodular BCC. Conclusions: BCC can show spontaneous substantial or complete regression. Histological tumor absence in lesions which are clinically suspicious for a neoplasm can be a hint for a regressive BCC. Recurrences may develop from remaining tumor islands warranting periodical clinical visits in cases of clinically as well as histologically suspected regressive BCC. %I Karger Publishers