A., Marsch K., Macha G., Siedler L., Breuer E.F., Strasser T., Engelhorn A., Dörfler S., Schwab B., Kallmünzer Supplementary Material for: Direct Oral Anticoagulant Plasma Levels for the Management of Acute Ischemic Stroke <b><i>Introduction:</i></b> The management of acute ischemic stroke in patients on direct oral anticoagulants (DOACs) is challenging. However, the substance-specific plasma level could guide treatment decisions on recanalization therapies. We present a plasma-level-based protocol for emergency treatment of stroke patients on oral anticoagulants. Bleeding complications and clinical outcome for patients on DOACs are reported and compared to patients on vitamin K antagonists (VKAs). <b><i>Methods:</i></b> In patients with acute ischemic stroke and suspected use of DOACs within 48 h prior to hospital admission, plasma levels were measured using the calibrated Xa-activity (apixaban, edoxaban, rivaroxaban) or the Hemoclot®-assay (dabigatran). Levels <50 ng/mL were supportive for thrombolysis, while high values >100 ng/mL excluded patients from recombinant tissue plasminogen activator use. For patients on VKAs, the cutoff was set at international normalized ratio of 1.7. Endovascular thrombectomy of a large vessel occlusion was performed independently from coagulation testing. Consecutive patients were included in an observational registry. <b><i>Results:</i></b> Five hundred and twenty-two patients (261 on VKAs and 261 on DOACs) were included. Thirty patients (11.5%) on VKAs and 24 (9.2%) on DOACs received thrombolysis, followed by mechanical thrombectomy in 10 and 14 patients, respectively. Seventeen patients in each group received thrombectomy only. Symptomatic intracranial hemorrhage associated with thrombolysis occurred in 1 patient on VKA (3.3%) and 1 on DOAC (4.2%; <i>p</i> = 0.872). The turnaround time of specific assays did not show a significant delay in comparison to standard coagulation parameters. <b><i>Conclusion:</i></b> DOAC plasma levels could support decisions on emergency treatment of ischemic stroke. Systemic thrombolysis below suggested thresholds appears preliminary feasible and safe without an excess in bleeding complications. Ischemic stroke;Oral anticoagulation;Direct oral anticoagulant;Plasma level;Thrombolysis;Thrombectomy 2019-09-04
    https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Direct_Oral_Anticoagulant_Plasma_Levels_for_the_Management_of_Acute_Ischemic_Stroke/9767513
10.6084/m9.figshare.9767513.v1