10.6084/m9.figshare.9777635.v1 Portela F. Portela F. Ministro P. Ministro P. deDeus J. deDeus J. Cravo M. Cravo M. Cotter J. Cotter J. Duque G. Duque G. Ferreira F. Ferreira F. Rosa B. Rosa B. Ferreira P.L. Ferreira P.L. Dias C.C. Dias C.C. Magro F. Magro F. Portuguese IBD Study Group (GEDII) Portuguese IBD Study Group Supplementary Material for: Health-Related Quality of Life in Patients with Moderate to Severe Ulcerative Colitis: Surgical Intervention versus Immunomodulatory Therapy Karger Publishers 2019 Health-related quality of life Ulcerative colitis Immunomodulatory Surgery 2019-09-06 09:34:44 Dataset https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Health-Related_Quality_of_Life_in_Patients_with_Moderate_to_Severe_Ulcerative_Colitis_Surgical_Intervention_versus_Immunomodulatory_Therapy/9777635 <b><i>Purpose:</i></b> Ulcerative colitis (UC) can be managed with immunomodulation or surgery. We aimed to understand whether these strategies had a different impact on patients’ health-related quality of life (HRQoL). <b><i>Methods:</i></b> This was a retrospective, cross-sectional study: patients who had a moderate to severe UC episode that prompted the utilization of immunomodulatory drugs or surgery were invited to complete a generic (short form [36] health survey [SF-36]) and a disease-specific (inflammatory bowel disease questionnaire [IBDQ]) survey. <b><i>Results:</i></b> We included 157 patients, 65 (41.4%) surgically treated. The therapeutic procedure had a minimal impact on HRQoL: only the social dimension of the IBDQ and the physical function component of the SF-36 were significantly different between the study arms – lower for the surgically treated patients. The type of surgery had no impact, but the occurrence of pouchitis, namely, in a chronic form, was associated with a lower HRQoL. Regression analysis confirmed surgery as an independent predictor of lower scores in the social dimension of the IBDQ (–4.646, 95% CI –6.953 to –2.339) and in the physical functioning (–9.622, 95% CI –17.061 to –2.183) and physical role functioning (–3.669, 95% CI –7.339 to 0.001) dimensions of the SF36. <b><i>Conclusions:</i></b> Although usually feared by patients, surgery has a limited impact on UC patients HRQoL when compared to medical management with immunomodulatory drugs.