J.R., Foucher C., deBilly L.C., Jeanjean A., Obrecht O., Mainberger J.M.E., Clauss B., Schorr M.C., Lupu P.L., deSousa J., Lamy V., Noblet E.A., Sauleau L., Landré F., Berna Supplementary Material for: A Brain Imaging-Based Diagnostic Biomarker for Periodic Catatonia: Preliminary Evidence Using a Bayesian Approach Periodic catatonia (PC) is a psychomotor phenotype with a progressive-remitting course. While it can fit any disorder diagnosis of the schizoaffective spectrum, its core features consist of a mix of hypo- and hyperkinesias resulting in distortions of expressive movements such as grimacing and parakinesias. The replication of cerebral blood flow (CBF) increases in the left supplementary motor area (L-SMA) and lateral premotor cortex (L-LPM) in acute and remitting PC patients indicates that these increases could be used as diagnostic biomarkers. In this proof-of-concept study, 2 different MRI sequences were repeated on 3 separate days to get reliable measurement values of CBF in 9 PC and 26 non-PC patients during different cognitive tasks. Each patient was compared to 37 controls. In L-SMA [–9; +10; +60] and L-LPM [–46; –12; +43], a test was positive if the <i>t</i> value was >2.02 (α < 0.05; two tailed). The measurements had good analytical performance. Regarding the tests, their sensitivities and specificities were significantly different from the chance level on both measures, except for L-SMA sensitivities. When combining all the tests, among regions and methods, sensitivity was 98% (95% credible interval [CI] 76–100%) and specificity 88% (72–97%). Bayesian inferences of its negative predictive values for PC were >95% regardless of the context, while its positive predictive values reached 94% but only when used in combination with clinical criteria. The case-by-case analysis suggests that non-PC patients with neurological motor deficits are at risk to be false positive. Periodic catatonia;Biomarkers;Functional brain imaging;Regional cerebral blood flow;Schizophrenia;Endogenous psychoses 2019-09-10
    https://karger.figshare.com/articles/dataset/Supplementary_Material_for_A_Brain_Imaging-Based_Diagnostic_Biomarker_for_Periodic_Catatonia_Preliminary_Evidence_Using_a_Bayesian_Approach/9791147
10.6084/m9.figshare.9791147.v1