K., Utano S., Katsuki T., Matsuda K., Mitsuzaki T., Fujita D., Nemoto K., Nagata A.K., Lefor K., Togashi Supplementary Material for: Colon Capsule Endoscopy versus CT Colonography in Patients with Large Non-Polypoid Tumours: A Multicentre Prospective Comparative Study (4CN Study) <b><i>Background/Aims:</i></b> Non-polypoid colon lesions compared with polypoid lesions has a high malignant potential. The diagnostic performance of colon capsule endoscopy (CCE) and CT colonography (CTC) for large colorectal non-polypoid tumours, that is, laterally spreading tumours is still unclear. The aim of this study is to evaluate the performance of CCE and CTC for the diagnosis of large non-polypoid tumours. <b><i>Methods:</i></b> Thirty patients referred for endoscopic submucosal dissection of non-polypoid tumours measuring ≥20 mm were enrolled. Patients first underwent CCE, then colonoscopy (without resection) and CTC on the same day. An experienced gastroenterologist in a third hospital evaluated the CCE and recorded the location, size and morphology of all lesions detected, blinded to the colonoscopic findings. An experienced radiologist read the CTC under the same conditions. Colonoscopic findings were defined as the reference. <b><i>Results:</i></b> A total of 30 lesions (T1 cancer: 3, T<i>is</i> cancer: 7, adenoma: 14, sessile serrated adenoma/polyp: 6) in 27 patients were observed for evaluation. The capsule excretion rate within 8 h was 85% (23/27), and all capsules went beyond the target lesions. Non-polypoid tumours tend to be depicted as polypoid on CCE. Per patient sensitivities were 0.89 (24/27) by CCE and 0.70 (19/27) by CTC (<i>p</i> = 0.0253, McNemar), and per lesion sensitivities were 0.87 (26/30) and 0.67 (20/30) respectively (<i>p</i> = 0.0143). Most lesions missed by both modalities were located in the proximal colon. <b><i>Conclusion:</i></b> Eighty-seven per cent of non-polypoid tumours were detected by CCE, and the sensitivity using CCE was higher than that obtained using CTC (UMIN0000014772). Colon capsule endoscopy;Computed tomographic colonography;Non-polypoid tumour;Laterally spreading tumour 2019-10-01
    https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Colon_Capsule_Endoscopy_versus_CT_Colonography_in_Patients_with_Large_Non-Polypoid_Tumours_A_Multicentre_Prospective_Comparative_Study_4CN_Study_/9923645
10.6084/m9.figshare.9923645.v1