erratum.pdf (29.18 kB)
Erratum: RETRACTION: Intraoperative Touch Imprint Cytological Analysis of Sentinel Lymph Nodes for the Presence of Metastases in Breast Cancer
dataset
posted on 2017-07-25, 13:21 authored by Tamiolakis D., Papadopoulos N., Venizelos J., Lambropoulou M., Romanidis C., Petrakis G., Limberis V., Galazios G., Koutsougeras G., Simopoulos C.Background: Imprint cytology may provide a fast and accurate
method for intraoperative screening of sentinel lymph nodes,
so a decision can be made regarding whether to perform axillary
clearance during primary surgery. If the findings are negative,
in many cases axillary dissection can be omitted. Patients
and Methods: 128 sentinel nodes from a cohort of 87 patients
that had been identified using technetium-99m nanocolloid as a
radioactive tracer and Patent blue dye were disected for rapid
Diff-Quick stained touch preparations. Intraoperative evaluation
of sentinel node status by imprint cytology was correlated with
histopathological results of permanent sections. Tumor-negative
nodes in routine paraffin sections were further investigated
with the employment of an anti-cytokeratin antibody. Results:
36 of all sentinel nodes harbored metastases in the paraffin sections,
of which 32 were identified by imprint cytology (sensitivity
88.8%). 3 sentinel nodes were positive by imprint cytology
and negative by histopathology of the paraffin sections. Comparison
of the results of the touch preparations with the final
histopathology (hematoxylin-eosin and anticytokeratin antibody
stains) demonstrated a sensitivity of 83.3% and a negative
predictive value of 92.5%. The specificity and positive predictive
value were 100% each. Conclusions: Touch imprint cytology is
potentially useful for intraoperative evaluation of sentinel
lymph nodes in breast cancer patients.