Supplementary Material for: A Systematic Review of Phytotherapy for Acute Rhinosinusitis

Herbal medicine is a promising alternative in the treatment
of acute rhinosinusitis (ARS). We performed a systematic
review for phytopharmaceutical treatments of
ARS. A computerized search of databases (Cochrane Library,
PubMed, and Scopus) up to 16 September 2015
was performed. Randomized controlled trials (RCTs) and
controlled trials (CTs) were included and assessed using
the Cochrane risk of bias tool. Seven trials on Pelargonium
sidoides (EPs 7630, Umckaloabo®), Myrtol (Gelo-
Myrtol® forte), BNO 1016 (Sinupret® extract), BNO 101
(Sinupret®), Cyclamen europaeum (Nasodren®), and Esberitox
® were included. Risk of bias was heterogeneous.
EPs 7630 appeared to be useful in the treatment of ARS.
Myrtol showed benefits against a placebo compound,
and BNO 1016 and BNO 101 might be helpful; however,
there was little evidence for the effectiveness of Cyclamen
europaeum and Esberitox®. Herbal medicine might
be effective for the treatment of ARS, but given the low
number of clinical trials and the heterogeneous methodological
quality, further research is necessary.