Supplementary Material for: Association of <i>AHSG</i> Gene Polymorphisms and Aortic Stiffness in Peritoneal Dialysis Patients
2010-05-07T00:00:00Z (GMT) by
<i>Background/Aims:</i> Fetuin-A is a negative acute-phase reactant and extraosseous calcification inhibitor. Decreased serum concentration of fetuin-A is independently related to all-cause and cardiovascular mortality in dialysis patients. Our aim is to investigate the association between the genetic polymorphism of α<sub>2</sub>-Heremans-Schmid-glycoprotein <i>(AHSG)</i> encoding fetuin-A and its serum concentration, vascular calcification, and aortic stiffness in peritoneal dialysis (PD) patients. <i>Method:</i> A total of six single nucleotide polymorphisms (SNPs) in the <i>AHSG</i> gene were genotyped and evaluated for association with serum fetuin-A level, quantitative measures of vascular calcification and aortic stiffness represented by heart-to-femoral pulse wave velocity (hfPWV). <i>Results:</i> Five SNPs in the <i>AHSG</i> gene were nominally associated with the serum fetuin-A level in our PD patients. In haplotype analyses, there were haplotypes positively (H1; AGCA, H2; CC) and inversely (H1; TTCG, H2; TT) related with the serum fetuin-A level. The serum fetuin-A level inversely and independently correlated with hfPWV. Moreover, the serum fetuin-A concentration was a determinant for the simple vascular calcification score (SVCS), which subsequently was associated with hfPWV. <i>Conclusions:</i> Our study showed an association between <i>AHSG</i> polymorphism and its serum concentration, and also revealed an association of the serum fetuin-A level with SVCS and aortic stiffness in PD patients.