Supplementary Material for: Risk Factors for Skin Infections in Mycosis Fungoides

2017-03-02T08:52:38Z (GMT) by Lebas E. Arrese J.E. Nikkels A.F.
<p><b><i>Background:</i></b> Mycosis fungoides (MF) is the most frequent type of primary cutaneous natural killer and T-cell lymphoma. MF-required immunosuppressive therapies and MF-related immunosuppressive characteristics render patients with MF more prone to infections. <b><i>Aim:</i></b> To describe the clinical features of cutaneous infections observed in MF patients. <b><i>Materials and Methods:</i></b> A series of 56 MF patients were followed prospectively over 3 years and screened for cutaneous infections. <b><i>Type of Study:</i></b> Prospective observational study. <b><i>Results:</i></b> Four herpes simplex virus type-I (HSV-I), 2 staphylococcal (<i>S. aureus</i>) impetiginizations and 2 <i>Malassezia</i> infections were detected in single isolated plaque/patch stage MF as well as 1 varicella zoster virus infection (herpes zoster, HZ) and 2 cases of cellulitis in 10 patients. All patients presented advanced MF. All the diagnoses were delayed due to atypical clinical presentations. <b><i>Conclusions:</i></b> Patients with advanced MF should be particularly monitored for skin infections, especially by HSV and <i>S. aureus</i>. Unexplained exacerbation or the sudden appearance of oozing or ulcerations in MF lesions should initiate a search for viral or bacterial agents. Cellulitis and HZ can be severer and prolonged in MF patients.</p>