Karger Publishers
Browse
1/1
4 files

Supplementary Material for: The Bidirectional Association between Inflammatory Bowel Disease and Atopic Dermatitis: A Systematic Review and Meta-Analysis

dataset
posted on 2020-01-17, 09:34 authored by Shi X., Chen Q., Wang F.
Background: Previous investigations have suggested a significant association between inflammatory bowel disease (IBD) and atopic dermatitis (AD). Yet, outcomes published remain inconsistent. Objective: To explore the association between IBD and AD by a systematic review and meta-analysis. Methods: A comprehensive search of studies published from March 1, 1968, to July 26, 2019, was performed in electronic databases as follows: PubMed, Embase, Cochrane Library, and Web of Science. Methodological quality was assessed based on the Newcastle-Ottawa Scale. Data analysis was conducted using R version 3.6.1 (meta package version 4.9-7). Results: A total of 14 studies were eligible for exploring the association between IBD and AD. Statistically significant differences were found on the risk of AD comorbidity among patients with IBD (risk ratio [RR] 1.83, 95% CI 1.39–2.40), Crohn’s disease (CD; RR 2.06, 95% CI 1.61–2.64), and ulcerative colitis (UC; RR 1.66, 95% CI 1.23–2.24). Compared with non-AD subjects, patients with AD were 48% (p = 0.019), 44% (p = 0.002), and 38% (p = 0.000) more likely to exhibit IBD, CD as well as UC, respectively. Discussion: Our evidence supported a significant bidirectional association between IBD and AD. Future prospective studies are warranted to explore underlying mechanisms linking them.

History

Usage metrics

    Dermatology

    Categories

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC