Supplementary Material for: Changes in osteoblastic bone metastasis detected incidentally by cone-beam computed tomography: A case report
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posted on 2025-03-13, 06:55 authored by figshare admin kargerfigshare admin karger, Hiya U., Endo M., Okada K., Takahashi S., Ogawa K., Nakagawa M., Nakamura M., Shibayama C., Fukuda Y., Akahane K., Kawahara M., Mori H., Shirai K.Introduction: Although cone-beam computed tomography (CBCT) is essential for tumor positioning in image-guided radiotherapy, its diagnostic application is limited by low image quality. This report highlights a case where CBCT unexpectedly detected osteoblastic bone metastasis during radiotherapy for prostate cancer.
Case Presentation: A 65-year-old man with recurrent prostate cancer underwent postoperative intensity-modulated radiotherapy (IMRT) of 66 Gy in 33 fractions. Two months after treatment, an increase in prostate-specific antigen (PSA) levels led us to perform imaging that revealed a new osteoblastic metastasis in the left acetabulum. A retrospective review of the CBCT scans obtained during radiotherapy showed progressive osteoblastic changes that were not visible on pre-treatment imaging.
Conclusion: The progressive changes in osteoblastic bone metastases on CBCT highlight its potential usefulness in daily monitoring and evaluation during radiotherapy.
