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Supplementary Material for: Endoscopic diagnosis of epithelial subtypes of superficial non-ampullary duodenal epithelial tumors using magnifying narrow-band imaging.

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posted on 2024-05-10, 05:48 authored by Kurata Y., Hirose T., Kakushima N., Nakaguro M., Okumura Y., Tanaka H., Fujishiro M., Kawashima H.
Introduction: Superficial non-ampullary duodenal epithelial tumors (SNADETs) include low-grade adenoma (LGA) and high-grade adenoma or carcinoma (HGA/Ca), and are classified into two different epithelial subtypes, gastric-type (G-type) and intestinal-type (I-type). We attempted to distinguish them by endoscopic characteristics including magnifying endoscopy with narrow-band imaging (M-NBI). Methods: Various endoscopic and M-NBI findings of 286 SNADETs were retrospectively reviewed and compared between G- and I-types and histological grades. M-NBI findings were divided into four patterns based on the following vascular patterns; absent, network, intrastructural vascular (ISV), and unclassified. Lesions displaying a single pattern were classified as mono-pattern and those displaying multiple patterns as mixed-pattern. Lesions showing CDX2 positivity were categorized as I-types and those showing MUC5AC or MUC6 positivity were categorized as G-types based on immunohistochemistry. Results: Among 286 lesions, 23 (8%) were G-type and 243 (85%) were I-type. More G-type lesions were located oral to papilla (91.3% vs 45.6%, P<0.001), and had protruding morphology compared to those of I-types (65.2% vs 14.4%, P<0.001). The major M-NBI pattern was ISV in G-type (78.2% vs 26.3%, P<0.001), and absent for I-type (0% vs 34.5%, P=0.003). Three endoscopic characteristics; location oral to papilla, protruding morphology and major M-NBI pattern (ISV) were independent predictors for G-type. Mixed-pattern was more common in HGA/Ca than LGA for I-type (77.0% vs 58.8%, P=0.01); however, there was no difference for those in G-type. Conclusion: Endoscopic findings including M-NBI is useful to differentiate epithelial subtypes.


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