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Supplementary Material for: Inter-Rater Agreement in the Clinical Diagnosis of Cognitive Status: Data from the Neurological Disorders in Central Spain 2 Pilot Study

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posted on 12.07.2016, 08:48 by Llamas-Velasco S., Sierra-Hidalgo F., Llorente-Ayuso L., Herrero-San Martín A., Villarejo Galende A., Bermejo Pareja F.
Background: To assess the diagnostic agreement of cognitive status (dementia, mild cognitive impairment (MCI), normal cognition) among neurologists in the field of neurological disorders in Central Spain 2 study. Methods: Full medical histories of 30 individuals were provided to 27 neurologists: 9 seniors, 10 juniors and 8 residents. For each case, we were asked to assign a diagnosis of dementia, MCI or normal cognition using the National Institute on Aging-Alzheimer's Association workgroup (NIA-AA) core clinical criteria for all-cause dementia, Winblad et al. criteria for MCI, and analyze intensity and etiology if dementia was diagnosed. Inter-rater agreement was assessed both with percent concordance and non-weighted ? statistics. Results: Overall inter-rater agreement on cognitive status was ? = 0.76 (95% CI 0.65-0.86), being slightly higher among junior neurologists (? = 0.85, 95% CI 0.73-0.95) than among seniors (? = 0.71, 95% CI 0.59-0.83) and residents (? = 0.69, 95% CI 0.54-0.81) but without statistical significance among groups. Dementia severity showed an overall ? of 0.34, 0.44 and 0.64 for mild, moderate and severe dementia respectively. Conclusions:Substantial agreement was demonstrated for the diagnosis of cognitive status (dementia, MCI and normal cognition) among neurologists of different levels of experience in a population-based epidemiological study using NIA-AA and Winblad et al. criteria. The agreement rate was lower in the diagnosis of dementia severity.

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