Supplementary Material for: International online survey on the management of patent ductus arteriosus

Introduction There is uncertainty and lack of consensus regarding optimal management of patent ductus arteriosus (PDA). We aimed to determine current clinical practice in PDA management across a range of different regions internationally. Materials and Methods We surveyed PDA management practices in neonatal intensive care units using a pre-piloted web-based survey, which was distributed to perinatal societies in 31 countries. The survey was available online from March 2018 to March 2019. Results There were 812 responses. The majority of clinicians (54%) did not have institutional protocols for PDA treatment and 42% reported variable management within their own unit. Among infants <28 weeks (or <1000g), most clinicians (60%) treat symptomatically. Respondents in Australasia were more likely to treat PDA pre-symptomatically (44% vs 18% all countries [OR 4.1; 95% CI 2.6-6.5; p<0.001]) and respondents from North America were more likely to treat symptomatic PDA (67% vs 60% all countries [OR 2.0; 95% CI 1.5-2.6; p<0.001]). In infants ≥28 weeks (or ≥1000g), most clinicians (54%) treat symptomatically. Respondents in North America were more likely to treat PDAs in this group of infants conservatively (47% vs 38% all countries [OR 2.3; 95% CI 1.7-3.2]; p<0.001) and respondents from Asia were more likely to treat the PDA pre-symptomatically (21% vs 7% all countries [OR 5.5; 95% CI 3.2-9.8; p<0.001]). Discussion/Conclusion There were marked international differences in clinical practice, highlighting ongoing uncertainty and a lack of consensus regarding PDA management. An international conglomeration to coordinate research that prioritises and addresses these areas of contention is indicated.