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Supplementary Material for: Potential Role of the Galectin-9/TIM-3 Axis in the Disparate Progression of SARS-CoV-2 in a Married Couple: A Case Report

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posted on 19.04.2021, 09:11 by Martín-Quirós A., Maroun-Eid C., Avendaño-Ortiz J., Lozano-Rodríguez R., ValentínQuiroga J., Terrón V., Montalbán-Hernández K., García-Garrido M.A., MuñozdelVal E., delBalzo-Castillo Á., Rubio C., Cubillos-Zapata C., Aguirre L.A., López-Collazo E.
We report the disparate clinical progression of a couple infected by SARS-CoV-2 based on their immune checkpoint (IC) levels and immune cell distribution in blood from admission to exitus in patient 1 and from admission to discharge and recovery in patient 2. A detailed clinical follow-up accompanied by a longitudinal analysis of immune phenotypes and IC levels is shown. The continuous increase in the soluble IC ligand galectin-9 (Gal-9) and the increment in T-cell immunoglobulin and mucin domain-containing 3 (TIM-3) protein in T cells in patient 1 suggests an activation of the Gal-9/TIM-3 axis and, subsequently, a potential cell exhaustion in this patient that did not occur in patient 2. Our data indicate that the Gal-9/TIM-3 axis could be a potential target in this clinical setting, along with a patent effector memory T-cell reduction.

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