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Supplementary Material for: Status epilepticus and low-grade glioma in the pregnant state: case report and ethical considerations

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Version 2 2024-07-03, 12:34
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posted on 2024-07-03, 12:34 authored by Waack A.L., Lucarelli V.M., Marellapudi A., Gega A., Zillgitt A.J., Staudt M.D.
The pregnant state may cause or exacerbate existing neurological disease. Gliomas appear to be influenced by the physiological changes that occur during pregnancy. The pregnant state may also cause seizures, including status epilepticus. There are currently no defined treatment guidelines to direct clinical decision making, and many of the commonly employed therapies are contraindicated during pregnancy. The current article describes the case of a 40-year-old G3P1101 female at 10 weeks gestation, who sought medical care for recurrent left hemifacial twitching, eventually leading to non-convulsive status epilepticus. Intubation and sedation were required to achieve seizure cessation. Imaging revealed a lobulated cystic mass in the right parietal lobe, suspicious for low-grade glioma. Despite thorough explanation of the potential risks, the patient adamantly wished to pursue surgical intervention. An uneventful craniotomy was performed for resection of a low grade glioma. No patient or fetal complications were encountered, and the patient has not had any reported seizures since surgery. Managing complex neurosurgical diseases in pregnant patients provides both clinical and ethical quandaries. We describe the successful management of a patient presenting with status epilepticus caused by an underlying glioma during pregnancy. Although challenging, favorable neurosurgical outcomes are possible during pregnancy.

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