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Supplementary Material for: The Influence of Pain on Reduced Quality of Life in Patients with Hidradenitis Suppurativa: A Single-Center Retrospective Study

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posted on 2023-09-16, 05:53 authored by Li Y., Speck P., Viera E., Siira M., Orenstein L.A.V.
Background: Pain and itch are impactful and burdensome symptoms of hidradenitis suppurativa (HS). Elucidating factors associated with pain and itch severity may identify groups disproportionally affected by HS-related pain and itch and further our understanding of how pain and itch impact quality of life (QoL) in patients with HS. Objective: To determine factors associated with pain severity, itch severity, and reduced quality of life in patients with HS. Methods: This is a retrospective cross-sectional study of 257 adults with HS who received care in an HS Specialty Clinic from January 2019 to August 2021. Multivariable mixed effects linear regression was used to determine the relationships between clinical and demographic patient factors and the outcomes of pain severity, itch severity, and skin-specific quality of life (QoL). Results: Factors associated with reduced QoL were Hurley Stage II (β=19.66, 95% CI: 1.40 -37.93) and III (β=21.98, 95% CI: 1.57-42.39) disease as well as severity of pain (β=13.74, 95% CI: 11.93-15.55), itch (β=4.57, 95% CI: 2.59-6.55), anxiety (β=2.55 95% CI:1.29-3.81), and depression (β= 1.43, 95% CI: 0.30-2.56). Increasing HS pain severity was associated with Hurley Stage III disease (β=2.04, 95% Cl: 0.99 – 3.09), Black race (β=1.23, 95% Cl: 0.40, 2.06), depression severity (β=0.08, 95% Cl: 0.02, 0.14), and anxiety severity (β=0.10 95% Cl: 0.04, 0.17). Factors associated with HS itch severity were Hurley Stage III disease (β=2.23, 95% Cl: 1.19, 3.27), Black race (β=0.92, 95% Cl: 0.07, 1.78), depression severity (β=0.09, 95% Cl: 0.04, 0.14), and anxiety severity (β=0.07, 95% Cl: 0.01, 0.13). Conclusion: Pain is one of the largest contributors to QoL in patients with HS; on a 0-10 numeric rating scale, a 2-point increase in HS pain had a similar independent effect on QoL as having Hurley stage III disease compared to Hurley stage I.


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