Supplementary Material for: Baseline Blood Pressure was Associated With Hemispheric Cerebral Blood Flow in Acute Small Subcortical Infarcts

Introduction: While increased baseline blood pressure (BP) is a prevalent comorbidity in the acute phase of ischemic stroke, the association between baseline BP and the state of hemispheric perfusion in patients with acute small subcortical infarcts (SSIs) has not been studied in detail. The aim of this study was to investigate the relationship between baseline BP and hemispheric cerebral blood flow (CBF) in acute SSIs. Methods: This retrospective study included 101 patients with acute SSIs. Baseline hemispheric CBF was assessed through co-registration of baseline CT perfusion imaging and follow-up diffusion-weighted imaging (DWI). The association between baseline BP, CBF, and different cerebral small vessel disease (CSVD) biomarkers was assessed. Results: Baseline systolic BP (SBP) and diastolic BP (DBP) were negatively associated with contralateral hemispheric CBF after multivariate-adjusted linear analysis (SBP: β=-0.001, 95%CI: -0.002-0.000, P=0.030; DBP: β=-0.002, 95%CI: -0.003~0.001; P=0.006). Among other CSVD biomarkers, the presence of any cerebral microbleeds (CMBs) showed a significant association with lower CBF in the contralateral hemisphere of the infarct lesion (r=-0.270, P=0.035). Conclusion: In patients with acute SSIs, increased baseline BP was associated with reduced CBF in the contralateral hemisphere of the infarct lesion, which probably could be interpreted by the exacerbation of the CSVD burden, suggesting a potential mechanistic link between blood pressure auto-regulation dysfunction and the aggravation of neurovascular impairment in SSIs.